Research
We have selected 10 published research papers that explore the diverse uses, medical applications, and the significant health benefits of using pearl powder for healing and overall well-being.
Calcium bioavailability of nanonized pearl powder for adults
H S Chen 1, J H Chang, J S B Wu
https://pubmed.ncbi.nlm.nih.gov/19021809/This study evaluated the calcium bioavailability of nanonized pearl powder for human adults and found that pearl powder was absorbed twice as efficiently as traditional calcium carbonate in clinical trials. It was therefore concluded that pearl powder is a beneficial source of calcium for adults and that nanonization improves its calcium bioavailability.
Pearl Powder—An Emerging Material for Biomedical Applications: A Review
Xian Jun Loh,1,* David James Young,2 Hongchen Guo,3 Liang Tang,3 Yunlong Wu,4 Guorui Zhang,3 Changming Tang,3 and Huajun Ruan3,*
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197316/This review explores the diverse biomedical applications of pearl powder, a traditional Chinese medicine used for over a thousand years. The paper highlights its potential in wound healing, bone repair, and skin treatment due to its rich protein and mineral content. Recent research has shown pearl powder’s effectiveness in promoting cell growth, osteogenesis, and antioxidant activity. The document also discusses pearl signal proteins, which are unique anti-aging substances that help renew, regenerate, and restore cells. Additionally, pearl’s benefits extend to bone health, as it can stimulate new bone growth and strengthen existing bones.
Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
Hui-Fang Chiu a , Su-Chun Hsiao b , Yan-Ying Lu c , Yi-Chun Han b , You-Cheng Shen d , Kamesh Venkatakrishnan b , Chin-Kun Wang b
https://pubmed.ncbi.nlm.nih.gov/29389568/The article explores the efficacy of protein-rich pearl powder on antioxidant status through a randomized placebo-controlled trial. It highlights how pearl powder can enhance antioxidant levels, potentially reducing oxidative stress and promoting overall health, as well as addressing age related degenerative diseases.
Nacre Extract from Pearl Oyster Shell Prevents D-Galactose-Induced Brain and Skin Aging.
Yamamoto, H., Shimomura, N., Oura, K., & Hasegawa, Y. (2023). Marine biotechnology (New York, N.Y.), 25(4), 503–518
https://doi.org/10.1007/s10126-022-10192-2The research explores the protective effects of nacre extract against aging induced by D-galactose, a sugar known to accelerate aging, in both brain and skin tissues. The study demonstrates that nacre extract can mitigate oxidative stress and inflammation, which are key contributors to aging processes. By enhancing antioxidant defenses and reducing inflammatory markers, the extract shows potential in preserving cognitive function and maintaining skin health.
Nacre extract restores the mineralization capacity of subchondral osteoarthritis osteoblasts.
Brion, A., Zhang, G., Dossot, M., Moby, V., Dumas, D., Hupont, S., Piet, M. H., Bianchi, A., Mainard, D., Galois, L., Gillet, P., & Rousseau, M. (2015). Journal of structural biology, 192(3), 500–509. https://doi.org/10.1016/j.jsb.2015.10.012
https://pubmed.ncbi.nlm.nih.gov/26496825/The research highlights nacre’s osteogenic properties, demonstrating its ability to enhance the mineralization capacity of osteoblasts, which are crucial for bone formation. This is particularly significant in the context of osteoarthritis, where joint cartilage and underlying bone degenerate. By restoring the mineralization process, nacre extract may improve bone health and potentially slow the progression of osteoarthritis.
Effects of pearl powder extract and its fractions on fibroblast function relevant to wound repair
Dai Jian-Ping, Chen Jun, Bei Yu-Fei, Han Bang-Xing, Guo Shang-Bin & Jiang Li- Li
https://www.tandfonline.com/doi/full/10.3109/13880200903046211This study explores the effects of pearl powder extract on fibroblast function, which is crucial for wound repair. The research highlights that the water-soluble matrix (WSM) of pearl powder, promotes oral fibroblast proliferation and collagen production. It also suggests that pearl powder’s bioactive components may stimulate cellular activities that promote tissue regeneration and wound healing.
Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial
Hui-Fang Chiu 1, Su-Chun Hsiao 2, Yan-Ying Lu 3, Yi-Chun Han 2, You-Cheng Shen 4, Kamesh Venkatakrishnan 2, Chin-Kun Wang 2
https://pubmed.ncbi.nlm.nih.gov/29389568/This investigates the antioxidant efficacy of protein-rich pearl powder in a randomized, placebo-controlled trial. Conducted with 20 participants, the study highlights that the protein content in pearl powder significantly contributes to its antioxidant activity. This activity was shown to potentially extend the lifespan of *Caenorhabditis elegans*, a model organism often used in aging research. Both in vivo and in vitro results suggest that pearl powder could be a potent antioxidant, offering protection against age-related degenerative diseases.
Extraction, Purification, Bioactivities and Application of Matrix Proteins From Pearl Powder and Nacre Powder: A Review
Jingying Pei 1,†, Yan Wang 1,2,†, Xianguo Zou 1,2, Huajun Ruan 3,*, Changming Tang 3, Jie Liao 3, Guangjie Si 3, Peilong Sun 1,2,*
https://pmc.ncbi.nlm.nih.gov/articles/PMC8095667/This review provides a comprehensive overview of the extraction, purification, bioactivities, and applications of matrix proteins from pearl and nacre powders. The study highlights the significant potential of these proteins, particularly in wound healing and bone regeneration. The review also explores the antioxidant, anti-inflammatory, and osteogenic activities of these proteins, making them promising for therapeutic use.
The Application of Pearls in Traditional Medicine of China and Their Chemical Constituents, Pharmacology, Toxicology, and Clinical Research
Yinglian Song, Wanyue Chen, Ke Fu, Zang Wang
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.893229/fullThis study provides an in-depth look at the use of pearls in traditional Chinese practices, for over 2,000 years, valued for their calming effects and ability to improve cognitive function. Chemically, pearls are composed of calcium carbonate, trace elements, and amino acids. They are also shown to exhibit anti-epileptic, bone-regenerative, and antioxidant properties, while also supporting cardiovascular health. Toxicological studies confirm their safety for long-term use.
Anti-inflammatory and anti-osteoporosis activities of pearl powder by inhibition of RANKL-induced osteoclastogenesis.
Wang, J., Wang, X., Zhao, C., Ma, S., Zhang, S., & Wang, H. (2003).
Journal of Ethnopharmacology, 113(2), 289-295.
Published in the Journal of Ethnopharmacology, this research explores the anti-inflammatory and anti-osteoporosis activities of pearl powder, with a focus on its inhibition of RANKL-induced osteoclastogenesis. This process is crucial in bone resorption and osteoporosis development. The study highlights that pearl powder effectively inhibits the differentiation and activity of osteoclasts, the cells responsible for bone breakdown, by interfering with the RANKL signaling pathway. This inhibition helps prevent excessive bone loss, making pearl powder a promising natural remedy for osteoporosis.
